abstract：:Converging lines of evidence from epidemiological studies and animal models now indicate that the origins of obesity and related metabolic disorders lie not only in the interaction between genes and traditional adult risk factors, such as unbalanced diet and physical inactivity, but also in the interplay between genes...

journal_title：Experimental physiology

authors： Taylor PD,Poston L

更新日期：2007-03-01 00:00:00

abstract：:Exercise induces a marked increase in interleukin-8 (IL-8) mRNA and protein expression within skeletal muscle fibres. Interleukin-8 belongs to a subfamily of CXC chemokines containing a Glu-Leu-Arg (ELR) motif. CXC chemokines with ELR motifs are potent angiogenic factors in vivo, and IL-8 has been shown to act as an a...

journal_title：Experimental physiology

authors： Frydelund-Larsen L,Penkowa M,Akerstrom T,Zankari A,Nielsen S,Pedersen BK

更新日期：2007-01-01 00:00:00

abstract：:In the present study, we tested the hypothesis that chronic intermittent hypoxia (CIH) produces changes in the autonomic and respiratory responses to acute peripheral chemoreflex activation. To attain this goal, 3-week-old rats were exposed to 10 days of CIH (6% O(2) for 40 s at 9 min intervals; 8 h day(-1)). They wer...

journal_title：Experimental physiology

authors： Braga VA,Soriano RN,Machado BH

更新日期：2006-11-01 00:00:00

abstract：:Exposure to whole-body vibration is implicated as one of the occupational risk factors for lower back disorders; however, its influence on the lumbar muscle physiology is still poorly understood. The objective of this study was to investigate the effects of backrest support and hand grip contractions on lumbar muscle ...

journal_title：Experimental physiology

authors： Maikala RV,Bhambhani YN

更新日期：2006-09-01 00:00:00

abstract：:All eukaryotic cells utilize oxidative phosphorylation to maintain their high-energy phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and cell survival is threatened when cells are deprived of O(2). Consequently, all cells have the ability to sense O(2), and to activate adaptive proce...

journal_title：Experimental physiology

authors： Guzy RD,Schumacker PT

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to compare the kinetics of estimated capillary blood flow (Qcap) to those of femoral artery blood flow (QFA) and estimated muscle oxygen uptake (VO2m). Nine healthy subjects performed a series of transitions from rest to moderate (below estimated lactate threshold, 6 min bouts) knee exten...

journal_title：Experimental physiology

authors： Harper AJ,Ferreira LF,Lutjemeier BJ,Townsend DK,Barstow TJ

更新日期：2006-07-01 00:00:00

abstract：:This study presents a perfused preparation for evaluation of metabolism in pig intercostal muscle in vitro. Preserved vessels and nerves to an intercostal segment including two adjacent ribs allowed for tissue perfusion and electrical stimulation with measurement of contraction force, oxygen consumption and 31P-magnet...

journal_title：Experimental physiology

authors： Pedersen BL,Arendrup H,Secher NH,Quistorff B

更新日期：2006-07-01 00:00:00

abstract：:Despite its critical role in restoring cardiac rhythm and thus in saving human life, cardiac defibrillation remains poorly understood. Further mechanistic inquiry is hampered by the inability of presently available experimental techniques to resolve, with sufficient accuracy, electrical behaviour confined to the depth...

journal_title：Experimental physiology

authors： Trayanova N

更新日期：2006-03-01 00:00:00

abstract：:It has been shown previously that the amplitudes of the harmonic components of the pulse spectrum vary in specific patterns when the arteries leading to different organs are ligated, with the variations in the harmonics being linearly additive. Since ligation can be regarded as a vast increase in organ resistance, the...

journal_title：Experimental physiology

authors： Hsu TL,Chao PT,Hsiu H,Wang WK,Li SP,Wang YY

更新日期：2006-01-01 00:00:00

abstract：:Interdigestive intestinal motility, and especially phase III of the migrating myoelectric/motor complex (MMC), is responsible for intestinal clearance and plays an important role in prevention of bacterial overgrowth and translocation in the gut. Yet previous results from gnotobiotic rats have shown that intestinal mi...

journal_title：Experimental physiology

authors： Lesniewska V,Rowland I,Laerke HN,Grant G,Naughton PJ

更新日期：2006-01-01 00:00:00

abstract：:A considerable body of evidence indicates that the intracellular chloride concentration ([Cl-]i) is an important regulatory signal in epithelial ion transport. [Cl-]i regulates the open channel probability of sodium and chloride channels, the rate of chloride channel recycling to the apical membrane, cell volume homeo...

journal_title：Experimental physiology

authors： Treharne KJ,Crawford RM,Mehta A

更新日期：2006-01-01 00:00:00

abstract：:The autonomic adjustments to exercise are mediated by central signals from the higher brain (central command) and by a peripheral reflex arising from working skeletal muscle (exercise pressor reflex), with further modulation provided by the arterial baroreflex. Although it is clear that central command, the exercise p...

journal_title：Experimental physiology

authors： Williamson JW,Fadel PJ,Mitchell JH

更新日期：2006-01-01 00:00:00

abstract：:Our aim was to analyse endothelial hypoxic preconditioning after hypoxia-reperfusion (HR). Endothelial functionality was analysed through the vasorelaxation responses to acetylcholine (Ach) and the level of serine1177 phosphorylated endothelial nitric oxide synthase (eNOS) (ser1177-eNOS) measured by Western blot in in...

journal_title：Experimental physiology

authors： Carrasco-Martín C,Alonso-Orgaz S,De la Pinta JC,Marques M,Macaya C,Barrientos A,González MM,García-Méndez A,Mateos-Cáceres PJ,Porres JC,Rico LA,López-Farré AJ

更新日期：2005-07-01 00:00:00

abstract：:The effect of resistance training on arterial stiffening is controversial. We tested the hypothesis that resistance training would not alter central arterial compliance. Young healthy men (age, 23 +/- 3.9 (mean +/- s.e.m.) years; n = 28,) were whole-body resistance trained five times a week for 12 weeks, using a rotat...

journal_title：Experimental physiology

authors： Rakobowchuk M,McGowan CL,de Groot PC,Bruinsma D,Hartman JW,Phillips SM,MacDonald MJ

更新日期：2005-07-01 00:00:00

abstract：:Therapeutic angiogenesis/vasculogenesis holds promise for the cure of ischaemic disease. The approach postulates the manipulation of spontaneous healing response by supplementation of growth factors or transplantation of vascular progenitor cells. These supplements are intended to foster the formation of arterial coll...

journal_title：Experimental physiology

authors： Madeddu P

更新日期：2005-05-01 00:00:00

abstract：:A global and transient rise of intracellular Ca2+ (Ca2+i) is central to the operation of pump-leak coupling in the frog early distal tubule (EDT). The endoplasmic reticulum (ER) is the site of this Ca2+ release and reuptake; however, it is likely that other intracellular pools, such as mitochondria, also contribute to...

journal_title：Experimental physiology

authors： Fowler MR,Hunter M

更新日期：2005-03-01 00:00:00

abstract：:It is now well accepted that the sympathetic nervous system responds to specific afferent stimuli in a unique non-uniform fashion. The means by which the brain transforms the signals from a single type of receptor into an appropriate differential sympathetic output is discussed in this brief review. The detection of a...

journal_title：Experimental physiology

authors： Coote JH

更新日期：2005-03-01 00:00:00

abstract：:A great variety of viruses have been engineered to serve as expression vectors. Among them, the alphaviruses Semliki Forest virus and Sindbis virus represent promising tools for heterologous gene expression in a wide variety of host cells. Several applications have already been described in neurobiological studies, in...

journal_title：Experimental physiology

authors： Rhême C,Ehrengruber MU,Grandgirard D

更新日期：2005-01-01 00:00:00

abstract：:The present study was designed to analyse the effects of aerobic exercise on the metabolic effects of alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight)(-1)) intraperitoneally (A rats). Vehicle-injected rats were used as controls (C rats). At 28 days old, some of the A rats were s...

journal_title：Experimental physiology

authors： de Oliveira CA,Luciano E,de Mello MA

更新日期：2005-01-01 00:00:00

abstract：:The cardiovascular response to isometric exercise is governed by both central and peripheral mechanisms. Both metabolic and mechanical stresses on the exercising skeletal muscle produce cardiovascular change, yet it is often overlooked that the afferent signal arising from the muscle can be modified by factors other t...

journal_title：Experimental physiology

authors： Fisher JP,White MJ

更新日期：2004-11-01 00:00:00

abstract：:The present study investigated the absolute reliability (R(Ab)) of isometric measures of time-to-peak tension (TTP), half-rise time ((1/2)RT), half-fall time ((1/2)FT), twitch force (TW(f)) tetanic force (TET(f)) and the sag ratio as applied to the slow soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) ...

journal_title：Experimental physiology

authors： Gallo M,Gordon T,Tyreman N,Shu Y,Putman CT

更新日期：2004-09-01 00:00:00

abstract：:Six untrained, male subjects (23 +/- 1 years old, 84 +/- 5 kg, (O(2)peak)= 3.7 +/- 0.8 l min(-1)) exercised for 60 min at 75 +/- 1%(O(2)peak) on 7 consecutive days. Muscle samples were obtained before the start of cycle exercise training and 24 h after the first and seventh exercise sessions and analysed for citrate s...

journal_title：Experimental physiology

authors： Kraniou GN,Cameron-Smith D,Hargreaves M

更新日期：2004-09-01 00:00:00

abstract：:Chronic heart failure (CHF) impairs muscle O2 delivery (QO2) and, at a given O2 uptake (VO2), lowers microvascular O2 pressures (PmvO2: determined by the QO2-to-VO2 ratio), which may impair recovery of high-energy phosphates following exercise. Because CHF preferentially decreases QO2 to slow-twitch muscles, we hypoth...

journal_title：Experimental physiology

authors： McDonough P,Behnke BJ,Musch TI,Poole DC

更新日期：2004-07-01 00:00:00

abstract：:This study investigated the role of nitric oxide (NO) and superoxide anions in modulating the renal nerve-dependent increases in proximal tubular fluid reabsorption (Jva). Renal nerve stimulation at 0.75 and 1.0 Hz (15 V, 0.2 ms) in anaesthetized Wistar rats had no effect on glomerular filtration rate but decreased ur...

journal_title：Experimental physiology

authors： Wu XC,Johns EJ

更新日期：2004-05-01 00:00:00

abstract：:The Flinders sensitive line (FSL) rats exhibit an increased cholinergic responsiveness in vivo when compared to their counterparts, the Flinders resistant line (FRL) rats. The functional consequences of this phenotypic difference on colonic mucosal function are not known. We sought to determine whether isolated distal...

journal_title：Experimental physiology

authors： Prior T,Hernandez J,Tougas G,Rangachari PK

更新日期：2004-03-01 00:00:00

abstract：:The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e. how the combined effects of hypoxia and hypercapnia exert a greater effect on afferent nerve discharge than ...

journal_title：Experimental physiology

authors： Peers C

更新日期：2004-01-01 00:00:00

abstract：:For synaptic and cellular analyses of the mammalian respiratory network, intracellular recording and good pharmacological access to respiratory neurones is required. Using an existing arterially perfused in situ preparation of neonatal rat, we report on a method allowing stable intracellular recordings of ventrolatera...

journal_title：Experimental physiology

authors： Dutschmann M,Paton JF

更新日期：2003-11-01 00:00:00

abstract：:The aims of this study were: (1) to determine the within-subject, between-day variability in end-tidal P(CO2) (P(ET,CO2)); (2) to determine whether the within-subject, between-day variability in P(ET,CO2) was caused by variations in metabolic acid-base status; and (3) to determine whether between-subject variations in...

journal_title：Experimental physiology

authors： Crosby A,Robbins PA

更新日期：2003-09-01 00:00:00

abstract：:Previous studies have shown that prolactin administration to pregnant rats results in offspring with enhanced abundance of the brown adipose tissue-specific uncoupling protein (UCP) 1. The present study therefore aimed to determine whether a similar effect was observed after birth and if the sex of the animal further ...

journal_title：Experimental physiology

authors： Pearce S,Dieguez C,Gualillo O,Symonds ME,Stephenson T

更新日期：2003-07-01 00:00:00

abstract：:Gastric distension in anaesthetized pigs reflexly elicits peripheral vasoconstriction and an increase in plasma renin activity (PRA), with vagal afferent and sympathetic efferent limbs. The aim of the present study was to quantify the contribution of the renin-angiotensin system to the peripheral vasoconstriction. In ...

journal_title：Experimental physiology

authors： Molinari C,Battaglia A,Grossini E,Florio S,Mary DA,Vassanelli C,Vacca G

更新日期：2003-05-01 00:00:00

abstract：:Mammalian cardiomyocytes have limited regenerative capacity, such that cell death can result in a net loss of viable contractile elements and a decrease in cardiac functional reserve, both during normal ageing and after insults to the myocardium leading to heart failure. At least four types of cell death have been des...

journal_title：Experimental physiology

authors： Goldspink DF,Burniston JG,Tan LB

更新日期：2003-05-01 00:00:00

abstract：:The aim of the present work was to investigate the role of the serotoninergic system in the control of sodium appetite of hypothyroid rats (HTR) by administering drugs that affect the serotoninergic activity, and to compare the same homeostatic behaviour in euthyroid rats (ETR) also given these drugs. Fenfluramine (FE...

journal_title：Experimental physiology

authors： Badauê-Passos D Jr,Ventura RR,Silva LF,Olivares EL,Reis LC

更新日期：2003-03-01 00:00:00

abstract：:Salivary fluid secretion is dependent upon reflex stimuli mediated by autonomic nerves. In order to determine if immunoglobulin A (IgA) and salivary proteins are secreted in the absence of nerve stimulation, small volumes (< 2 microl) of saliva were consecutively collected from the submandibular duct of anaesthetised ...

journal_title：Experimental physiology

authors： Proctor GB,Carpenter GH,Segawa A,Garrett JR,Ebersole L

更新日期：2003-01-01 00:00:00

abstract：:This review explores the current concepts relating the structural and functional modifications of skeletal muscle mitochondria to the molecular mechanisms activated when organisms are exposed to a hypoxic environment. In contrast to earlier assumptions it is now established that permanent or long-term exposure to seve...

journal_title：Experimental physiology

authors： Hoppeler H,Vogt M,Weibel ER,Flück M

更新日期：2003-01-01 00:00:00

abstract：:Three experiments were performed to see whether cardiac neurons contribute to the intrinsic control of heart rate in right atria of adult rats. The intrinsic heart rate response (IRR) was examined by raising right atrial pressure from 2 to 8 mmHg for 3 min. In isolated preparations of the right atrium, the IRR was not...

journal_title：Experimental physiology

authors： Wilson SJ,Bolter CP

更新日期：2002-11-01 00:00:00

abstract：:The present study was designed to investigate the renal responses to hypotensive haemorrhage early in life and the role of renal sympathetic nerves in modulating these renal responses. To this end, experiments were carried out in conscious, chronically instrumented lambs with either intact renal nerves (n = 7, Intact)...

journal_title：Experimental physiology

authors： Smith FG

更新日期：2002-09-01 00:00:00

abstract：:Recently attempts have been made to analyse blood pressure (BP) and renal sympathetic nerve activity (RSNA) to determine how patterns contained within them might reflect control by the autonomic nervous system. To date, these studies have primarily used coherence analysis of BP and RSNA in the frequency domain. Howeve...

journal_title：Experimental physiology

authors： Yang Z,Zhang T,Coote JH

更新日期：2002-07-01 00:00:00

abstract：:The vasoregulatory role of nitric oxide (NO) and angiotensin II type 1 (AT(1)) receptors in the circulation of the submandibular gland (SMG) of rats was studied. The glandular blood flow was determined by means of laser Doppler flowmetry and rubidium isotope technique. The data obtained by these two methods correlated...

journal_title：Experimental physiology

authors： Vág J,Kerémi B,Hably C,Bartha J,Fazekas A

更新日期：2002-05-01 00:00:00

abstract：:The renal medulla contains more mRNA of the inducible isoform of nitric oxide synthase (iNOS) than the cortex, which may be important in preventing ischaemic injury, since blood flow and tissue oxygen tension are normally low in this region. We examined the effects of the bacterial endotoxin E. coli lipopolysaccharide...

journal_title：Experimental physiology

authors： Chou DE,Cai H,Jayadevappa D,Porush JG

更新日期：2002-03-01 00:00:00

abstract：:The dorsal horn of the spinal cord plays an important role in transmitting information from nociceptive primary afferent neurones to the brain; however, our knowledge of its neuronal and synaptic organisation is still limited. Nociceptive afferents terminate mainly in laminae I and II and some of these contain substan...

journal_title：Experimental physiology

authors： Todd AJ

更新日期：2002-03-01 00:00:00